In theory, it is possible to run about any x86 based operating system. So I guess the short answer is 'yes, it's possible'.
However, the engineers at 3-Com decided that a thinned out QNX was the bext fit for Audrey because of it's speed and extremely small footprint. I tend to agree that it's probably the best OS to run on it. Seeing how they actually engineered the device with this OS in mind.
I would like to see Linux, or something else get ported just for the sake of experimentation. But for getting the best use out of Audrey, QNX has done me just fine.
I am still holding out for that graphical jabber client. Perhaps one day a skilled developer will get sick of my bitching and code one for use in photon.