It might be possible with the hardware that it comes with.
Cyrix Media GXm 200 MHz
8 Megs Flash
16-64 Megs DRAM
Currently running WinCE, and with the hardware spec, it is probably better to just leave it as is or run Linux,QNX, or DOS on it. The memory is upgradeable, but most likely the processor is not. Drivers may be a little hard to come by, but not impossible. Other than the PCMCIA slot, there is probably not another way to run a HD in this thing. If it doesn't come with an IDE header, the cost will be high to get something else running in this. Lastly, not sure how hard it will be to get into the BIOS of this thing.
For what it was intended originally, this thing is pretty good, but probably not extremely good for your casual hacker. More serious hackers this will be a different story ;)