No flames here please...
For what it is worth, I've been running my iOpener in my car for over 2 years now. GPS connected through a USB/Com adapter and sound hack...straight off the 12V adapter. I use the stock WinChip with the heat sink cut in half to mount the HD. I have yet to have any issues...
The iOpener has to convert whatever input power it receives to 12V (and 5V and 3.3V and 2V I believe) for use by the rest of the system. Input voltage from the car is 14.4 normally. One issue is that if the iOpener is running, and I have to start the car, the iOpener will reboot. The regular 110V/19V AC adapter puts out some fairly dirty power (depending on the input 110V power).
Just based on my usage in the car, I have found that the iOpener is a fairly durable piece of equipment. It needs to be cared for, but not handled with "kid gloves".
Texas weather being what it is (in the summer), some care has to be taken when the car is extremely hot. I have started the iOpener within a couple of minutes of starting the car/AC and have had not problems. Car is still fairly hot, but the iOpener has yet to have a problem.
I know that there are several posts about using a DC 12V/19V converter. I've yet to see the need. Of course, tomorrow I may have a different statement...
Hope this helps